|
 Dr. Lee is the founder and owner of Regrowth LLC, a company based in Los Angeles and dedicated to the treatment of hair loss. He has been developing innovative products and treating hair loss sufferers for the past 16 years. Dr. Lee is the creator of the Xandrox line of hair loss treatments.
Important Note: Due a busy schedule, Dr. Lee cannot answer any new questions at this time; however, he will be providing high quality answers to questions he receives from his own practice exclusively to Morphollica.com regularly
anonymous
2005-09-15
What are ASCJ products for hair loss?
What are ASCJ products and why might they become important in the treatment of MPB?
They are a group of novel anti-androgens being investigated by the
Androscience Corporation in San Diego. ASCJ products have the potential of
being safe and very effective topical medications for defeating the action of
DHT in the scalp. ASCJ is synthesized from a natural product and promotes the
degradation of endogenous androgen receptors. This pharmacological mechanism
differs completely from all currently available anti-androgens. In laboratory
tests, topically applied testosterone induced inhibition of the hair cycle
progression with prolongation of the telogen phase 50% of the time in the mouse
model. Whereas anagen conversion was achieved in 100% of the mice given
testosterone followed with ASCJ-9. The researchers concluded, “These
preliminary observations suggest that ASCJ-9 is a potential candidate for
effective and safe topical treatment of acne and male pattern baldness.”*
Currently, AndroScience is conducting GLP (Good Laboratory Practice) toxicology
and accumulating other preclinical data in order to file an IND
(Investigational New Drug application) and proceed to Phase I and II clinical
studies.
*Ching-Yuan Su “Effects of a Novel Anti-androgen on Rodent Models of Acne and
Testosterone – Dependent Suppression of Hair Cycle” presented at the summer
session of the American Academy of Dermatology 2005
Richard Lee, M.D.
Regrowth, LLC
Click here to return to Dr. Richard Lee, MD's Q&A page.
|
